I believe one of the greatest human failings is to prefer to be right than to be effective. Political correctness is always obsessed with how right it is without thinking how effective it might be. I do relish transgression and I deeply and instinctively distrust conformity and orthodoxy.

Stephen Fry

In the greater scheme, in the big picture, nothing we do matters. There’s no grand plan, no big win. If there's no great glorious end to all this, if nothing we do matters, then all that matters is what we do. Because that's all there is. What we do, now, today. And if there's no bigger meaning, then the smallest act of kindness is the greatest thing in the world.

Angel

If your ego starts out, 'I am important, I am big, I am special,' you're in for some disappointments when you look around at what we've discovered about the universe. No, you're not big. No, you're not. You're small in time and in space. And you have this frail vessel called the human body that's limited on Earth.

Neil deGrasse Tyson